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Cysteine is taken up by cells via the Glutamate/Cystine transporter xCT (SLC7A11), which has been found overexpressed in several cancers and is responsible for a novel way of cell death called ferroptosis (77)

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2022 Although N isoforms can also act as dominant-negative inhibitors of the full-length proteins and promote tumorigenesis in cells containing wild-type p53 and TAp73 13 in contrast to p53, mice lacking p73 show no increased susceptibility to spontaneous tumorigenesis

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