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Difluoromethylornithine combined with a polyamine transport inhibitor is effective against gemcitabine resistant pancreatic cancer

Reischl-Hajiabadi AT, Garbade SF, Feyh P, Weiss KH, Mtze U, Klker S, Hoffmann GF, Gramer G

Unfortunately, clinical trials using vitamin C were not reproducible

Given the susceptibility of Cys111 to oxidative modifications in SOD1-ALS and previous work on cisplatin and BMOE, we undertook a crystallographic screening of a small library of cysteine-reactive compounds known to have favourable properties (Supplementary Fig