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Abbreviations IL-6: Interleukin-6 6-AN: 6-Aminonicotinamide 2-DG: 2-Deoxyglucose 4OI: Itaconic acid AGEs: Advanced Glycated End products AKR1C1: Aldoketo reductase family 1 member C1 AMPK: AMP-activated protein kinase AMPs: Antimicrobial Peptides ATP: Adenosine Triphosphate BPI: Bactericidal/permeability-increasing protein Casp6: Caspase 6 CCRs: Chemokine Receptors CEBP- : CCAAT Enhancer Binding Protein-Alpha CEBP- : CCAAT Enhancer Binding Protein-Beta c-MPL: Thrombopoietin receptor CRISPR: Clustered Regularly Interspaced Short Palindromic Repeats CTLA-4: Cytotoxic T-Lymphocyte Antigen 4 CXCL3: Chemokine (C-X-C motif) ligand 3 DHAP: Dihydroxyacetone Phosphate DPI: Diphenylene iodonium EP2: Extracellular Protein 2 EP4: Extracellular Protein 4 ERK1/2: Extracellular signal-Regulated protein Kinases 1 and 2 eWAT: Epididymal White Adipose Tissue FAO: Fatty Acid Oxidation fMLP: F-Methionyl-Leucyl-Phenylalanine G6PDH: Glucose-6-Phosphate Dehydrogenase G-CSF: Granulocyte Colony Stimulating Factor GLUT: Glucose Transporter GSH: Glutathione HDP: Host Defence Peptides HFD: High Fat Diet HNP: Human Neutrophil Peptides IFN-: Interferon-Alpha IL-1: Interleukin-1Beta LDH: Lactate Dehydrogenase LILRB5: Leukocyte immunoglobulin-like receptor B5 LKB1: Liver kinase B1 LPS: Lipopolysaccharides MMP: Matrix Metalloproteinases MPO: Myeloperoxidase NADPH: Nicotinamide Adenine Dinucleotide Phosphate Hydrogen NE: Neutrophil Elastase NECTIN2: Nectin cell adhesion molecule 2 NETs: Neutrophil Extracellular Traps NF-B: Nuclear factor B Nrf2: Nuclear factor erythroid 2-related factor 2 PAD4: Peptidyl Arginine Deiminase 4 PAI1: Plasminogen Activator Inhibitor 1 PARP: Poly (ADP-ribose) polymerase PBMCs: Peripheral blood mononuclear cells PFK: Phosphofructokinase PKB: Protein kinase B PLPP3: Phospholipid phosphatase 3 PMA: Phorbol 12 myristate 13 acetate PPP: Pentose phosphate pathway PRRs: Pattern recognition receptors PTB-DM: Pulmonary tuberculosis with diabetes mellitus RAGE: Receptor for advanced glycation end products ROS: Reactive Oxygen Species SCFAs: Short Chain Fatty Acids SLC9A4: Solute carrier family 9 member A4 SOD: Superoxide Dismutase T1D: Type 1 diabetes T2D: Type 2 diabetes TB: Tuberculosis TCA: Tricarboxylic acid TGF-: Transforming Growth Factor-Alpha TGF-: Transforming Growth Factor-Beta THP1: Tamm-Horsfall Protein 1 TLR-4: Toll-Like Receptors TNF-: Tumor Necrosis Factor-Alpha References Frydrych LM, Bian G, OLone DE, Ward PA, Delano MJ

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doi: 10.1038/nature23007