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It's also one of the few ingredients commonly recommended for both post-inflammatory erythema (PIE) and post-inflammatory hyperpigmentation (PIH)

This term is often a point of discussion amongst sneaker fans, and mainly indicates that the sneakers are box-fresh, brand-new, and in top-tier condition

doi: 10.1126/science.abh2444 38 HanahanDWeinbergRA

This activation triggers the NF-B signaling cascade, leading to a transcriptional upregulation of pro-inflammatory cytokines (e.g., TNF-, IL-1, IL-6), chemokines, and adhesion molecules, which in turn recruit more immune cells to the injury site, and driving chronic inflammation and tissue damage (85)

Kamiski Marcin M, Sauer Sven W, Kamiski M, Opp S, Ruppert T, Grigaraviius P, et al

Science 301, 13741377.10.1126/science.1086907 131 WedemayerG