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A glutathione-based heavy metal mitigation approach proves effective by harnessing the natural detoxification properties of glutathione

[3] Sulfur itself is able to exist in several different oxidation states

doi: 10.1016/B978-0-12-800100-4.00003-9 25 WardmanJFBainsRKRahfeldPWithersSG

This elevated level induces oxidative stress, and lipid peroxidation results in the generation of ROS, which affect hepatocytes and decrease the synthesis of antioxidant enzymes

Glutathionylated proteins occur mainly in intracellular space because GSH is located in the cytoplasm and Cys residues of proteins are in a reduced form and able to form mixed disulfides

4b), decreased serum zonulin concentrations (Fig