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The ROS are generated by a number of cellular oxidative and metabolic processes including activity of the enzymes of the mitochondrial respiratory chain, xanthine oxidase, NADPH oxidase, monoamine oxidases, and metabolism of arachidonic acid (AA) mediated by the activity of lipoxygenases (LOX), and ROS are produced primarily by leakage of electrons in the mitochondrial respiratory chain [3]

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On the other hand, they observed that levels of claudin-2 were significantly increased in the aging group and not in the adult group

Moreover, the results of Liu and Gershon were essentially the same when their extended BrdU study was done in 5-HT 4 knock-out and wild-type mice

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Recent research has also demonstrated the importance of antioxidants in modulating metabolic pathways during infection