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[7] [8] Authorities in Switzerland have also allowed prescription of the drug for EPP with reimbursement approved by two unnamed insurers [9] Afamelanotide is currently being clinically trialled in the form of a "grain of rice" sized bioabsorbable subcutaneous implant as a potential therapeutic photoprotection inducing agent for a series of light related skin indications as well as a potential dermal repigmentation agent for vitiligo

In a rat model of iron deficiency anemia, expression and activity of eNOS were increased in the aorta and in the kidney (140), pointing to a further mechanism leading to increase in NO bioavailability in anemia

Funding We thank the Department of Health Science, Torrens University, and the Curtin School of Pharmacy and Biomedical Sciences for financial research support and excellent research facilities, respectively