glutathione activates toxic Toxicity of Glutathione-Binding Metals: A Review of Targets and Mechanisms Glutathione is such a critical

Although the effect of some ER-phagy pathways on sensory neuropathies suggests the importance of this process in the peripheral nervous system, it is difficult to know how important loss of this selective autophagy subtype is for the genesis of neurodegenerative diseases of the central nervous system

They work as support systems , not forceful triggers

Good management of patients

We used the scoring system described by Esaki et al [5]

Both endogenous PAs and exogenous application of PAs confer tolerance against different stresses including metals (Groppa et al., 2003

Modulation of Tyrosinase Expression Tyrosinase gene expression, together with Tyrp1 and Typr2, is induced by microphthalmia transcription factor (MITF), which is in turn regulated by signaling pathways, including cAMP/PKA/CREB, RAS/MEK/ERK, and -catenin pathways