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Human epidermal growth factor receptor 2 (HER2) promotes cell growth and division, and is frequently overexpressed in various cancers, notably ovarian and breast carcinomas [68]

Jun 28 2016;21(7)doi:10.3390/molecules21070844 Almaghrabi S, Adams M, Geraghty D, Ahuja K

Klingenberg M, Matsuda A, Diederichs S, Patel T

In this study we investigated the role of metformin in regulating intracellular redox status and cell survival in LNCaP prostate cancer cells

Meanwhile, the results of Western blot assay showed that the protein expression levels of Cyclin A2 , Cyclin E2 , c-MYC , Cyclin D1 and CDK2 were significantly increased in the RRM2 overexpression group, and Cyclin D1 , Cyclin E1/E2 and Cyclin A2 are important regulators driving the cell cycle process, and their high expression is often associated with the acceleration of G1/S phase transition

Glutamate Transporters and Receptors Excitatory Amino Acid Transporters Increased levels of extracellular glutamate, particularly asynchronistic glutamate levels, cause cellular damage when excitatory neurotransmission is sufficiently aberrant (Pitt et al., 2000