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It was further demonstrated that deletion of one Alox12 allele in mouse promotes lymphomagenesis in E-Myc models, and that ALOX12 missense mutations derived from human cancers lose their capabilities to oxygenate PUFA and to promote p53-mediated ferroptosis (Chu et al., 2019)

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To test this hypothesis, we investigated the effect of IIR on muscle insulin sensitivity during moderate-intensity continuous knee-extension exercise

The mammalian genome encodes five subtypes of the VEGF family, which are VEGF-A, VEGF-B, VEGF-C, VEGF-D, and placental growth factor (78)

This work was supported by National Institutes of Health (NIH) R01CA183989 and R01GM132142 to M.K., Chao Family Comprehensive Cancer Center Pilot Award, Cancer Center Support Grant P30-CA062203 (to University of California, Irvine), and the American Cancer Society Research Scholar (RSG-16-085-01-TBE)

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