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In addition to the consensus on the prominent role of cystine starvation in blocking GSH synthesis, the present two studies demonstrated two previously under-appreciated metabolic effects that contribute to the ferroptosis-susceptible state in cancer cells under cystine deprivation conditions: loss of GPX4 protein translation and accumulation of oxidative stress-inducing intracellular glutamate (Fig

Ferroptotic macrophages can trigger a systemic inflammatory response by releasing DAMPs and pro-inflammatory cytokines that can activate the inflammasome

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Huber M, Wachtlin J (2012) Vitreous levels of proteins implicated in angiogenesis are modulated in patients with retinal or choroidal neovascularization

Brain foods: The effects of nutrients on brain function

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