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All patients gave written informed consent to be treated, and the study using clinical data for research was approved by the medical ethical committee of the Slotervaart Hospital

Moreover, gonadotropin-releasing hormone (GnRH), FSH, LH, E2, and P4, which are hormones secreted by the hypothalamicpituitary-ovary axis, along with growth hormone (GH) and melatonin (MT), play a crucial role in maintaining normal reproductive and physiological functions in animals (1621)

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Also, there is limited evidence to suggest that selenium supplementation could be useful in the treatment of patients with KBD