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Based on data from animal studies (Rowley et al., 2012) and limited human data (Jasinski and Krishnan, 2009a), we hypothesized that lisdexamfetamine would have (i) a longer time to C max ( T max ) than D-amphetamine, (ii) a lower C max than D-amphetamine, (iii) an area under the amphetamine concentration-time curve that is identical to D-amphetamine, (iv) a smaller maximal effect ( E max ) and (v) a longer time to E max ( T max ) than D-amphetamine, and (vi) an area under the observed subjective drug effect-time curve that is identical to D-amphetamine

The sustained and growing body of research on this compound, spanning multiple countries, research institutions, and animal models, reflects a level of reproducibility that supports continued serious investigation

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Increasing public awareness reduces stigma and encourages early diagnosis

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It influences the expression of numerous genes responsible for cell proliferation, differentiation, and migration, essential for the repair of damaged tissues