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Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, et al

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Mechanisms by which the virus gains access into the mitochondria and cause dysfunction remain to be investigated

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While some retrospective studies suggest that metformin may confer a survival benefit for diabetic patients with solid tumors, including PDAC, randomized controlled trials have not found significant benefits for PDAC patients when metformin is combined with gemcitabine [109, 113]

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