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In the gut, KPV has an additional advantage

(1955) 26 WurtmanRJAxelrodJChuEW

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Following successful model induction, the Uricase and RBC@SeMSN@Uri groups received intravenous injections of 10 mg/kg Uricase or RBC@SeMSN@Uri at 0 h, coinciding with the cessation of fructose feeding

It is produced naturally in the body, mainly in the liver where it is synthesised from its precursor amino acids

Intestinal epithelial cells primarily degrade Trp via the kynurenine pathway, which is essential for regulating colonic inflammation and colorectal cancer [114]