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The complement cascade generates C5a , a potent anaphylatoxin that upregulates adhesion molecules and strongly attracts neutrophils

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J Comp Physiol B Biochem Syst Environ Physiol 176:653661

Mutations accumulate in mtDNA perhaps because the DNA is not packaged by histones and because mtDNA is positioned within the mitochondrion alongside the electron transport system and its byproducts, namely oxygen free radicals

However, this is a mixed observation, and careful monitoring in research protocols is key

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