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Whilst a handful of enterovirus vaccines are available, including for poliovirus (PV) and for EV-A71 (frequently responsible for serious outcomes of hand, foot and mouth disease) 1,2,3,4 , there are as yet no licenced anti-enterovirus drugs, despite evidence for efficacy in clinical trials and reports of extremely high potency for compounds targeting a pocket internal to capsid protein VP1 (termed here the P site) 5,6

PMID 19073424

Discussion 1) The results of this study completed by McCoy et al systematically evaluated the metabolic stability, BBB permeability, procognitive activity, and synaptogenic potential of Dihexa and other Nle-AngIV analogs, ultimately aiming to identify a therapeutic agent for dementia

There were 22 females and 13 males with the mean ages of 10.9, 14.9 and 11.7 years for the control, CKD1/2, and CKD3/4 groups, respectively

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At four feet away, our Ridgid top pick, we recorded a peak decibel level of 85 dB