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Side Effects Injection Site Reactions : Pain, redness, or itching at the injection site are typical adverse effects

It acts as a methyl donor through the betainemethionine pathway

PDE5 inhibitors can reduce the incidence of intestinal cancer by altering epithelial homeostasis via cGMP

Moreover, MAPK/ERK signaling upregulates Kruppel-like factor-2 (KLF2) and KLF4, which enhance eNOS expression, inhibit NF-B signaling, and suppress TNF- receptor expression, reinforcing anti-inflammatory and atheroprotective effects [207]