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Tian, L., Wu, D., Dasgupta, A., Chen, K

doi: 10.1148/radiol.231143, 72 GovorunovaE

Mirabegron, a beta3-adrenoceptor agonist, is currently under investigation as an alternative strategy to achieve weight loss by inducing browning of subcutaneous white adipose tissue and increasing energy expenditure

Additionally, increased levels of iron in specific brain regions further augment neuronal vulnerability to oxidative stress (29)

By further elucidating the pathogenic mechanism by which hepatic iron accumulation triggers ferroptosis through the c-Myc-Acsl4 regulatory axis, thereby accelerating the progression of metabolic-associated steatohepatitis (MASH), our research team identified a novel iron chelator, FOT1 (FerroTerminator1, formerly known as CN128), through drug screening, which can prevent and treat the onset and progression of MASH disease [117]

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