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### Why These Bodybuilding Peptides Fell Short Despite their popularity in the bodybuilding community, GHRP-based peptides had significant limitations: | Limitation | Details | |-----------|---------| | **Indirect mechanism** | Relied on GH release rather than directly targeting fat metabolism | | **Inconsistent results** | GH response varied dramatically between individuals | | **Appetite stimulation** | GHRP-6 massively increased hunger counterproductive for fat loss and getting slim | | **No major clinical trials** | Never studied in large, placebo-controlled Phase III trials for fat loss | | **Water retention** | GH elevation caused significant water retention, masking fat loss results | | **Cortisol/prolactin effects** | Some GHRPs elevated cortisol and prolactin catabolic and counterproductive for muscle building | | **Now banned** | All classified as FDA Category 2

Along with cracked corners of your mouth, signs of B12 deficiency include joint pain, numbness and tingling in hands and feet, depression or anxiety, and yellowing of the skin

Anion exchange (AEX) and cation exchange (CEX) chromatography methods were established, as described in a previous work (Supplementary Figure S7C)

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