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Larger stones, and stones that fail to pass or cause especially severe pain or obstruction and infection may require more aggressive therapies such as antibiotics, lithotripsy (therapy utilizing ultrasound shock waves to break stones into smaller fragments), or surgery to remove stones (Antonelli 2015)

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In order to improve the stability of 5-azacitidine and decitabine, a large number of second-generation cytidine analogs have been developed