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X-ray crystal structure of LET7 showing autoinhibition of the catalytic LET7 PPase domain (green) by binding to the N-terminal TPR domain (blue) (PDB code: 7OBE) (right panel)

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Through a systematic review, we identified that oxidative stress played a significant role in the pathogenesis of OA, and metformin had potential antioxidative capacity in relieving various chronic inflammation-related diseases, raising the possibility of treating OA

2026 Apr 30:14:e21194

DHEA and Cancer - DHEA, a key hormone, regulates the enzyme G6PD, which is crucial for cancer metabolism