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Introduction Oligodendrocytes are glial cells that synthesize myelin, a material that wraps around axons and facilitates neuronal conduction in the central nervous system ( OPCs are highly vulnerable to stress because their metabolic rate and intracellular iron are high, while their concentrations of the antioxidant glutathione are low ( The components of gintonin include lysophosphatidic acids (LPAs), ginseng major latex-like protein 151, and ginseng ribonuclease-like storage protein ( The pathogenesis of the myelin diseases can derive from various stages of oligodendrocyte development, including proliferation, differentiation, and myelination

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