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Therapeutic targets for treating fibrotic kidney diseases

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This study also centered on PGC-1s impact on mitochondrial biogenesis, while disregarding effects on mitophagy

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However, a significant limitation across many studies is the reliance on in vivo phenotypic readouts without robust in vitro mechanistic validation, making it difficult to distinguish direct immunomodulatory effects from secondary consequences

Struyfs, C., Cammue, B., and Thevissen, K., Front