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Metabolites involved in glycolysis/GNG (gluconeogenesis) and the tricarboxylic acid (TCA) cycle exhibited an overall increase in the SIRT1 CKO group, with statistically significant elevations in lactate, -ketoglutarate (-KG), and succinate levels (Fig

Food Chem 116(3):743747 Kassa SB, Taslimi P, zel , Gr B, Glin , Onganer Y (2022) Effects of some phenolic compounds on the inhibition of -glycosidase enzyme-immobilized on PluronicF127 micelles: an in vitro and in silico study

Under prolonged and increased ROS levels, oxidative stress occurs, which has been implicated in different types of regulated cell death

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This metabolic shunt enables Tm cells to bypass glycolysis-dependent energy production, maintaining functionality in nutrient-poor niches

However, this is not a sustainable strategy, as samples are typically provided for up to one month