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Tian W, Rojo de la Vega M, Schmidlin CJ, Ooi A, Zhang DD

Indeed, homocysteine neurotoxic properties have been attributed to NMDA receptor stimulation, auto-oxidation elevating oxidative stress, mitochondrial complex I inhibition, and allosteric D2 receptor antagonism (88)

In rats with collagen-induced arthritis (CIA), BM-MSC transplantation has been shown to inhibit the expression of cytokines associated with bone destruction, alleviate joint inflammation, and inhibit synovial proliferation and cartilage destruction

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It catalyzes the reductive transfer of an amino group from aspartate to -ketoglutarate to yield oxaloacetate and glutamate

To investigate the function of CBS in this process, we silenced its expression by CRISPR/cas9 mediated gene knockout strategy (sg CBS ) in SCD erythroblasts (Fig