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10.1016/j.phrs.2019.04.010 42 DuZ.WangJ.LuY.MaX.WenR.LinJ.et al (2020)

Clinical trials of drugs targeting amino acid metabolism This review synthesizes evidence underscoring a paradigm shift in our understanding of amino acids, recasting them from passive nutrients to active governors of the hepatic microenvironment

Reprogrammed proline metabolism supports HCC proliferation and confers drug resistance

In contrast, another estrogen deprived cell line, MCF-7:2A, appears to have elevated levels of glutathione (GSH) and is resistant to estradiol-induced apoptosis