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Gut serotonin regulation relies on a wider chemical repertoire: Bile-acid derivatives PABA (4-aminobenzoic acid) Tyramine Clostridia cluster metabolites importantly, these clusters (IV and XIVa) also contain many of the main butyrate producers, even though not all are spore-forming Together, they form the fast, potent, evolutionarily tuned chemistry that drives EC-cell serotonin signalling