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This study determined whether co-injections of L-NAC (500 mol/kg, IV) or its highly cell-penetrant analogue, L-NAC methyl ester (L-NACme, 500 mol/kg, IV), prevent acquisition of acute physical dependence induced by twice-daily injections of fentanyl (125 g/kg, IV), and overcome acquired dependence to these injections in freely-moving male Sprague Dawley rats

If appetite suppression feels adequate and side effects are manageable, hold at this dose

Furthermore, it inhibits inflammatory cascades by suppressing the COX enzyme and prostaglandin E-2 (PGE2), also influencing various molecular signaling pathways related to inflammation, apoptosis, and oxidative stress, like PPAR, PI3K, TLR-4, Akt, mTOR, ERK5, AP-1, TGF-, PAK1, Wnt, -catenin, Shh, Rac1, p38MAPK, EBP, NLRP3 inflammasome, Nrf2, Notch-1, AMPK, STAT3, and MyD-88, crucial in IBD development [504]

[6] Different approaches can be used to treat this disorder