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Senescence is triggered by various intrinsic and extrinsic factors, including DNA damage, telomere attrition, oncogene activation, and oxidative stress, as illustrated in Citation1 Understanding the molecular mechanisms underlying senescence is critical for developing interventions in aging-related diseases and cancer

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References Nogueiras, R., Nauck, M

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Research documents a 70% increase in collagen production in treated women compared to controls, outperforming both vitamin C and retinoic acid in comparative trials

This is when the provider assesses protocol response and makes any dose or frequency adjustments based on observed outcomes and patient feedback