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As this article is a review and does not report any new data collected by the authors, separate Institutional Review Board (IRB) or Ethics Committee approval was not sought or required for its preparation

We are going to include a graphic below, but we recommend having a professional healthcare practitioner show you the proper way to safely open your ampoules so that you do not injure yourself or lose any of the vitamin contents

Metformin, conversely, interferes with the calcium-dependent absorption of the B12-Intrinsic Factor complex in the terminal ileum (the end of the small intestine)

Patients should have routine complete blood counts (CBCs), vitamin B12 level checks, and neurological evaluations to facilitate early detection of potential complications and ensure effective management

For these reasons, the FDA-approved versions (Ozempic, Wegovy, Mounjaro, Zepbound) require a prescription