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The authors suggest that serum IGF-1 facilitates brain A removal by enhancing the transport of A carrier proteins (e.g., transthyroxine, apolipoprotein J, and albumin) across the BBB, thereby improving choroid plexus barrier transport and increasing A efflux from the brain, thereby regulating brain A clearance [183, 185]

Vitamin C contributes to the reduction of tiredness and fatigue

Collectively, these antioxidants contribute to the overall defense against oxidative stress in the gut, preventing cellular damage and inflammation

Therapeutically, targeting ferroptosis with rationally combined inhibitors, stimuli-responsive nanocarriers, and immunomodulators offers a promising precision strategy, provided that delivery systems are designed to tolerate the periodontal pocket environment

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LPS, mediated by CD14, initiates a signaling pathway from toll-like receptor 4 that leads to the activation of NF-B