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Circulating levels of reactive oxidative species and pro-inflammatory cytokines are elevated in type 2 diabetes, especially if there are microvascular or macrovascular complications which can lower GSH levels [5, 22]

2.4 Quinones and others: the balance between redox cycling and toxicity The chemical core of quinone compounds is the conjugated diketone structure within their molecules

Omega-3 fatty acids play a role in activating the Nrf2/ARE pathway, protecting neurons from oxidative damage, regulating the gut-brain axis, and regulating the balance of microflora

Determination of inflammatory markers To evaluate neuroinflammation in brain tissue treated with TMX and/or LC, proinflammatory markers such as tumor necrosis factor- (TNF-), interleukin-6 (IL-6), interleukin-1 (IL-1), and nuclear factor kappa B (NF-B) were measured by enzyme-linked immunosorbent assay (ELISA) kits obtained from ABclonal and Biosourse (USA), respectively, according to the manufacturers instructions for TNF- (ABclonal, cat no

doi: 10.1016/j.bbrc.2024.149788 30 ZhaoYZhengGYangSLiuSWuYMiaoYet al

Comput Electron Agric 143:2337 Kar RK (2011) Plant responses to water stress: role of reactive oxygen species