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When Nrf2 responses are inadequate, lipid peroxides can trigger inflammation through the nuclear factor kappa B (NF-B) pathway ( NF-B functions as a principal modulator of inflammatory processes ( Sirtuins, particularly SIRT1(Zhao et al., 2022b), are NAD-dependent deacetylases that regulate enzymes involved in fatty acid catabolism, such as AMPK, PPAR-, SREBP-1c, and Nrf2

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