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2015;94:e1849

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sFASL binds to the Fas receptor (CD95) on the surface of target cells, activating the caspase cascade and triggering programmed cell death

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This interaction is critical in breast cancer oncogenesis and progression, particularly as Bag-1 activity is enhanced by mutant p53, further promoting cell survival and resistance to apoptosis ( Figure 3 ) (57, 58)