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Description

Genetic testing in motor neurone disease

Ann Epidemiol

Biochemistry 39 , 1329513306 (2000)

The 2ml and 3ml vials suit single-peptide or lower-volume reconstitution, while the 10ml vial is more practical if you're reconstituting multiple peptide vials or running an extended research protocol

SDH and fumarate hydratase (FH) catalyze sequential steps in the TCA cycle, and their inactivation results in accumulation of succinate and fumarate, respectively, both of which are structural analogues of 2OG (succinate is also a product of the 2OG-dependent dioxygenase-catalyzed reactions) and have been shown to inhibit the PHD enzymes at pathophysiological concentrations