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Implications for therapeutic use The pharmacokinetic differences between SLU-PP-332 and 5-amino-1mq have significant implications for their therapeutic use: Dosing frequency: The rapid absorption and extensive distribution of SLU-PP-332 may allow for less frequent dosing compared to 5-amino-1mq

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However, studies using beta-3-adrenergic receptor knockout mice revealed a more complex picture: Long-term AOD-9604 treatment failed to produce weight loss in beta-3-AR knockout mice Acute administration still increased energy expenditure and fat oxidation in knockout mice This suggests beta-3-AR expression enhancement contributes to, but does not directly mediate, lipolytic effects The peptide appears to work through an unidentified receptor mechanism that subsequently influences beta-3-adrenergic signaling pathways

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