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For instance, antioxidants have been shown to protect zebrafish lateral-line hair cells from ototoxic damage, and mitochondrial transplantation, a novel form of therapy, enhances bioenergetics and mitigates oxidative stress-induced apoptosis in auditory cells (Holmgren and Sheets, 2020

Lipid peroxidation products such as oxidized phosphatidylethanolamine (PEox) generate hydroxyl radicals through the Fenton reaction, which directly damage cell membrane integrity and release toxic aldehydes (such as malondialdehyde, MDA) (172)

doi: 10.1177/0883073808321060 20

In addition, most recently, another di-substituted hydroxylamine, named OT551, able to cross blood-brain barrier (BBB) and inhibit OS and inflammation, has been developed and has shown efficacy in a phase-II clinical trial on age-related macular degeneration

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Interestingly, this one skews toward no-DAC, especially with pre-bed dosing