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Conclusion Acetaminophen acts not only on the brain but also the spinal cord and induces analgesia

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Nature 391 , 8286 (1998)

doi: 10.1039/d4fd00076e

The entry of these substances triggers a local inflammatory response within the brain tissue itself, characterized by microglial activation and the production of additional pro-inflammatory cytokines (Varatharaj and Galea, 2017