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Heffernan 2001a No hyperglycaemia observed in animal models even at doses producing significant fat oxidation

however, this is rare

In oxidative stress microenvironments, hydrophobic sulfides can be converted into hydrophilic sulfoxides and sulfones, thus facilitating the release of bioactive drugs [332]

The development of hyperkalemia associated with potassium-sparing diuretics is accentuated in the presence of renal impairment (see CONTRAINDICATIONS)