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Proline derivatives as a scaffold for new ASCT2-targeting drugs Five activators and two inhibitors are described with the intriguing findings of a proline derivative able to activate and another to inhibit transport mediated by rat ASCT2

doi: 10.1093/bja/aew214 187

Friedman AN, Chambers M, Kamendulis LM, Temmerman J

Striatal dopamine transporters, vesicular monoamine transporters (VMAT2), cortical and striatal D1 receptors and striatal dopamine D2/D3 receptors are decreased with advancing age [145, 151, 152]

Common symptoms of salicylate intolerance include: Skin: Itchy skin, hives, rashes, eczema, skin color changes Respiratory: Wheezing, asthma, breathing difficulties, nasal congestion, runny or blocked nose, sinusitis, nasal polyps Gastrointestinal: Stomach pain, nausea, vomiting, diarrhea, bloating, intestinal inflammation Head: Headaches, dizziness Eyes: Itchy, watery, or swollen eyes Other: Fatigue, light-headedness, sneezing, coughing Oxalate Intolerance Oxalates are naturally occurring compounds found in many plant-based foods

Over time, this process can result in fibrous collagen scars, or fibrosis, which can disrupt blood flow through the liver