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TRAF6 is a central adaptive protein involved in toll-like receptor and interleukin-1 receptor (IL-1R) signaling leading to nuclear factor-kappa B (NF-B) activation, which is vital for immune cell development, activation, and tolerance

Orhan Kili et al., 2021

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This process involves increased expression of molecular chaperones including heat shock proteins and glucose-regulated protein 78 (GRP78), which facilitate proper ferritin subunit assembly (Khadir et al., 2016)

Some stem cell transplant recipients must take immunosuppressive drugs for life, which can have serious side effects

Similarly, under oxidative stress, ROS can inhibit PTEN, a negative regulator of the PI3K pathway, leading to the activation of the PI3K-AKT signaling axis (196, 197)