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Homozygous individuals carrying the C667T allele have a threefold increased risk of developing premature cardiovascular disease [52,53] confirmed the risk factor of the thermolabile allele with coronary disease in a meta-analysis of dozens of independent studies [53]

10.1111/cns.14497 63 LiaoD.ShangguanD.WuY.ChenY.LiuN.TangJ.et al (2023)

That said, a good physician will consider changes in a patients lab work, as well as changes in how they feel

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1, Supplementary Table 4 show GO enrichments for proteins significant in the relevant categorical model outcomes only)