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Abstract Oncology has become one of the most influential and studied areas in both human and companion animal health

CD28 costimulation also increases the expression of Glut3, promotes glycolysis, and enhances CD8 + T cell function in renal cell carcinoma [172]

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According to (38), it also reduces markers of cellular senescence like lipofuscin aggregation and Iba1 immunoreactivity, proposing a role in the modulation of glial activation and oxidative stress