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Mechanistically, NLRP3 activation exacerbated pancreatic injury through caspase-1-dependent maturation of interleukin-1 (IL-1) and gasdermin D (GSDMD)-mediated pyroptosis, perpetuating systemic inflammation

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have shown that T regulatory cells (Tregs) upregulate FTH and iron trapping, compared to conventional T helper cells, to support Foxp3 transcription, Treg identity, immune tolerance and tumor progression [89] (Fig