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In xenografts from HCC patients with low LIFR but high LCN2 expression, sorafenib is insensitive to suppress tumor progression by inducing ferroptosis

In vitro hypoxia impairs beta2-adrenergic receptor signaling in primary rat alveolar epithelial cells

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Why it matters: During moderate-to-severe dehydration, plasma volume contracts, reducing cardiac output and oxygen delivery to tissues

And that has to do with some of the legality around clinical trials

However, in the presence of small quantities of CSH (or cystine), GSH becomes potent pro-oxidant that exacerbates the effect of CSH by donating reducing equivalents to regenerate free CSH