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Generally, in low intracellular calcium, the autoinhibitory domain binds with the kinase domain of the CDPKs, hence, restricting the target protein phosphorylation activity of the CDPKs

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10.1016/j.cell.2022.09.013 64 LiY.ChenL.ChenY.ShiH.YuS.FunmilayoA.et al

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Notably, recent findings have highlighted six novel high-priority RA risk loci, including RPP14 (DNASE1L3-ABHD6-PXK), PXT1 (ETV7), MIR5708 (TPD52), DDX6 (CXCR5), SUOX (CDK2), and PCAT29 (LOC145837) [27]

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