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(2021) Efficiency of the sublingual route in treating B12 deficiency in infants

Abbreviations CNS Central nervous system BDNF brain-derived neurotrophic factor CSF cerebrospinal fluid AD Alzheimers disease D H dopamine -hydroxylase A amyloid- APP amyloid precursor protein AA ascorbic acid AGEs advanced glycation end products RAGE receptors for AGE BBB blood brain barrier LRP-1 low-density lipoprotein receptor-1 GSH glutathione SSRIs selective serotonin reuptake inhibitors 4-HNE 4-hydroxynonenal MCI mild cognitive impairment ROS reactive oxygen species CDR Clinical Dementia Rating HPA hypothalamicpituitaryadrenal MMSE Mini-Mental State Examination CI confidence interval IQR inter-quartile range SMD standard mean deviation

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Although epithelium acts as a physical and antimicrobial barrier, ingested materials and enteric pathogens can promote inflammation by stimulating the production of proinflammatory cytokines, which further contribute to OS

Many of those studies demonstrated an acute beneficial effect, however, liver toxicity associate with frequent use of CGRP small molecule inhibitors has hampered progress

For example, it was added to dithranol and methotrexate in topical treatment of psoriasis Agarwal and colleagues, Javadzadeh and Hamishehkar