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After phosphorylation, it inhibits MITF from binding to a tyrosinase promoter and degrades it (Lee et al., 2021

While capable of converting immunologically cold tumors and enhancing checkpoint blockade efficacy, it requires precise modulation to avoid immunosuppressive counteradaptations [147]

It would also be of interest to determine whether ALDH1L2 expression or formate levels correlate with the response to immunotherapies in PDAC and other tumours

Elmaaty, K.M

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