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however, its long-term efficacy remains uncertain

If you prefer cooking your own tuna fillet, make note that the muscles right below the skin (the dark muscles) contain a high concentration of vitamin B12

10.1001/archinte.165.10.1167

Eur Neurol 58:9699 Tyagi N et al (2005) Mechanisms of homocysteine-induced oxidative stress

The pink color only shows up when a compounding pharmacy adds vitamin B12 to the formulation

[73] [74] [75] It is synthesized by some bacteria in the gut microbiota in humans and other animals, but it has long been thought that humans cannot absorb this as it is made in the colon, downstream from the small intestine, where the absorption of most nutrients occurs